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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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What is Cell Signaling?02:03

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Endocrine cells produce hormones to communicate with remote target cells found in other organs. The hormone reaches these distant areas using the circulatory system. This exposes the whole organism to the hormone but only those cells expressing hormone receptors or target cells are affected. Thus, endocrine signaling induces slow responses from its target cells but these effects also last longer.
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Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
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Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
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Studying Wnt Signaling During Patterning of Conducting Airways
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WNT Signaling in Disease.

Li Fang Ng1, Prameet Kaur1, Nawat Bunnag1

  • 1Division of Science, Yale-NUS College, Yale-NUS College Research Labs @ E6, E6, 5 Engineering Drive 1, #04-02, Singapore 117608, Singapore.

Cells
|August 7, 2019
PubMed
Summary

The WNT pathway, crucial for development and discovered in cancer, is increasingly linked to human diseases. This review covers WNT

Keywords:
Alzheimer’s diseaseWNTcancermetabolic syndrome

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Pathology

Background:

  • Developmental signaling pathways regulate critical biological processes from embryogenesis to adult life.
  • The WNT pathway, initially identified in cancer research and developmental biology, has broad implications.
  • Emerging evidence highlights the WNT pathway's involvement in diverse human pathologies.

Purpose of the Study:

  • To review the WNT pathway's fundamental role in human diseases.
  • To discuss recent advancements in understanding WNT's involvement in pathology.
  • To explore emerging WNT-related therapeutic strategies.

Main Methods:

  • Literature review of WNT pathway research.
  • Analysis of WNT pathway's role in embryogenesis and adult homeostasis.
  • Examination of WNT pathway dysregulation in human diseases.
  • Overview of current and developing WNT-targeted treatments.

Main Results:

  • The WNT pathway is essential for numerous developmental processes.
  • Aberrant WNT signaling is implicated in a wide spectrum of human diseases, including various cancers.
  • Significant progress has been made in developing therapies targeting the WNT pathway.

Conclusions:

  • The WNT pathway is a critical regulator of fundamental biological processes.
  • Dysregulation of the WNT pathway contributes significantly to human disease pathogenesis.
  • Targeting the WNT pathway holds promise for novel therapeutic interventions in multiple diseases.