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Coronary Circulation01:21

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Related Experiment Video

Updated: Jan 21, 2026

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
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Molecular Coronary Plaque Imaging Using 18F-Fluoride.

Alastair J Moss1, Mhairi K Doris1, Jack P M Andrews1

  • 1British Heart Foundation Centre for Cardiovascular Science (A.J.M., M.K.D., J.P.M.A., R.B., M.D., A.S.V.S., M.C.W., M.R.D., D.E.N., P.D.A.), University of Edinburgh, United Kingdom.

Circulation. Cardiovascular Imaging
|August 7, 2019
PubMed
Summary
This summary is machine-generated.

Coronary 18F-fluoride positron emission tomography (PET) precisely quantifies plaque vulnerability. This method demonstrates high reproducibility, supporting its use as a noninvasive biomarker for assessing atherosclerotic plaque risk.

Keywords:
angiographycomputed tomography angiographycoronary artery diseasefluoridesmyocardial infarction

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Area of Science:

  • Cardiovascular Imaging
  • Radiochemistry
  • Nuclear Medicine

Background:

  • Coronary 18F-fluoride PET identifies high-risk atherosclerotic plaques.
  • Optimal methods for quantifying and categorizing 18F-fluoride uptake are needed.
  • Reproducibility of coronary 18F-fluoride uptake measurements requires establishment.

Purpose of the Study:

  • To optimize the identification of increased coronary 18F-fluoride uptake.
  • To establish quantification and categorization methods for coronary 18F-fluoride activity.
  • To determine the scan-rescan reproducibility of coronary 18F-fluoride uptake.

Main Methods:

  • Prospective observational study involving patients with multi-vessel coronary artery disease.
  • Serial 18F-fluoride PET scans were performed.
  • Coronary 18F-fluoride activity was visually assessed, quantified (maximal tissue to background ratios), and categorized. Observer and scan agreement were determined.

Main Results:

  • Thirty patients underwent paired serial PET-CT angiography imaging.
  • A mean of 3.7±1.8 18F-fluoride positive plaques per patient were identified after acute coronary syndrome, versus 2.4±2.3 in stable CAD.
  • Low bias and good agreement were observed for maximal tissue to background ratio measurements between observers and scans. Visual assessment showed good agreement (κ=0.66) for focal uptake categorization.

Conclusions:

  • Coronary 18F-fluoride activity is a precise and reproducible metric in the coronary vasculature.
  • The analytical performance of 18F-fluoride is sufficient for assessing prognostic utility.
  • 18F-fluoride PET serves as a noninvasive imaging biomarker of plaque vulnerability.