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Review of systemic agents in the treatment of advanced cutaneous squamous cell carcinoma

Erik T Petersen1, Saqib R Ahmed1, Leon Chen2

  • 1University of Texas MD Anderson Cancer Center, Department of Dermatology, Mohs and Dermasurgery Unit, Houston, TX 77030, USA.

Future Oncology (London, England)
|August 7, 2019
PubMed

Insights

Advanced cutaneous squamous cell carcinoma (cSCC) is a rare but deadly form of skin cancer. Recent FDA approvals offer new hope, improving treatment options for this previously underserved patient group.

Area of Science:

  • Oncology
  • Dermatology
  • Medical Science

Background:

  • Advanced cutaneous squamous cell carcinoma (cSCC) represents a small fraction of cSCC cases but causes a significant proportion of deaths.
  • Historically, effective treatment options for advanced cSCC were limited due to poor efficacy, durability, and high treatment-related morbidity.

Purpose of the Study:

  • To review the systemic treatment modalities for advanced cSCC.
  • To analyze the historical evolution, current options, and future directions in managing advanced cSCC.

Main Methods:

  • Literature review of systemic treatment options for advanced cutaneous squamous cell carcinoma.
  • Analysis of treatment efficacy, response durability, and associated morbidities.
  • Speculation on future therapeutic developments.

Main Results:

  • The landscape of advanced cSCC treatment has significantly improved since the first FDA approval in Autumn 2018.
  • New systemic agents offer better response rates and durability compared to historical options.
  • Despite advancements, challenges remain in optimizing treatment and minimizing morbidity.

Conclusions:

  • The advent of new systemic therapies marks a paradigm shift in managing advanced cSCC.
  • Continued research is crucial for further improving outcomes and patient quality of life in advanced cSCC.
  • Future developments are expected to enhance the efficacy and tolerability of treatments for advanced cSCC.
Keywords:
advanced cutaneous squamous cell carcinomaimmunotherapytargeted therapy

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