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Nivolumab-induced lichen planus.

Mesut Yilmaz1, Sermin Guven Mese2, Ugur Celik3

  • 1Medical Oncology Department, Bakırköy Sadi Konuk Training and Research Hospital, İstanbul, Turkey.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|August 7, 2019
PubMed
Summary

Nivolumab, a PD-1 inhibitor, can cause immune-related adverse skin events like lichen planus. This case shows early diagnosis and topical treatment allowed uninterrupted cancer therapy.

Keywords:
Immune-related adverse eventimmunotherapylichen planusnivolumab

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Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Renal cell carcinoma (RCC) is the most common kidney malignancy.
  • Nivolumab, a PD-1 inhibitor, treats metastatic RCC post-antiangiogenic therapy.
  • Skin reactions are common side effects of anti-PD-1 antibodies.

Observation:

  • A young woman developed skin lesions after nivolumab treatment for advanced RCC.
  • Dermatological examination diagnosed the lesions as lichen planus.
  • The condition appeared after the ninth dose of nivolumab.

Findings:

  • Lichen planus is an immune-related adverse event associated with nivolumab.
  • Topical corticosteroids and clobetasol propionate cream effectively treated the skin lesions.
  • Complete regression of lesions occurred within one month.

Implications:

  • Early recognition and management of skin adverse events are crucial for maintaining cancer treatment.
  • Topical therapies can resolve nivolumab-induced lichen planus without interrupting immunotherapy.
  • This case highlights the importance of dermatological consultation for managing immune-related adverse events.