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Acute fibrinous and organizing pneumonia: two case reports and literature review

Jingjing Lu1, Qi Yin1, Yunlan Zha1

  • 1Department of Respiratory Medicine, Shanghai East Hospital, Tongji University School of Medicine, Pudong, 200120, Shanghai, China.

BMC Pulmonary Medicine
|August 7, 2019
PubMed
Abstract

Insights

Acute fibrinous and organizing pneumonia (AFOP) is a rare lung injury often misdiagnosed. Early diagnosis and corticosteroid treatment lead to good outcomes for patients with AFOP.

Area of Science:

  • Pulmonology
  • Pathology

Background:

  • Acute fibrinous and organizing pneumonia (AFOP) is a rare lung injury.
  • Characterized by alveolar "fibrin balls," it often presents with non-specific symptoms.
  • Misdiagnosis as pneumonia or tuberculosis is common, with lung biopsy required for definitive diagnosis.

Observation:

  • Two cases of AFOP with histopathological confirmation are presented.
  • Both patients showed significant improvement following corticosteroid therapy.
  • Review of previous literature on AFOP clinical and pathological characteristics was conducted.

Findings:

  • Corticosteroid therapy demonstrated effectiveness in treating AFOP.
  • Early identification and diagnosis are crucial for successful AFOP management.
  • Histopathological findings are key to distinguishing AFOP from other lung conditions.

Implications:

  • Improved understanding of AFOP aids clinicians in accurate diagnosis and treatment.
  • Timely and effective corticosteroid intervention improves patient prognosis.
  • This study highlights the importance of considering AFOP in cases of unexplained pneumonia.
Keywords:
Acute fibrinous and organizing pneumonia

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