Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lateralization01:28

Lateralization

979
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
979
Structural Organization of the Human Body: An Overview01:18

Structural Organization of the Human Body: An Overview

26.6K
It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms, and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of...
26.6K
Chromosome Structure02:40

Chromosome Structure

26.0K
A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
26.0K
Association Areas of the Cortex01:21

Association Areas of the Cortex

9.0K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.0K
Protein and Protein Structure02:15

Protein and Protein Structure

87.0K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
87.0K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.6K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The effects of task similarity during representation learning in brains and neural networks.

Nature communications·2025
Same author

Entorhinal grid-like codes for visual space during memory formation.

Nature communications·2025
Same author

Hippocampal-entorhinal cognitive maps and cortical motor system represent action plans and their outcomes.

Nature communications·2025
Same author

The Scope and Limits of Fine-Grained Image and Category Information in the Ventral Visual Pathway.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2024
Same author

A combined DTI-fMRI approach for optimizing the delineation of posteromedial versus anterolateral entorhinal cortex.

Hippocampus·2024
Same author

Causal role of the angular gyrus in insight-driven memory reconfiguration.

eLife·2024

Related Experiment Video

Updated: Jan 21, 2026

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.8K

Mapping sequence structure in the human lateral entorhinal cortex.

Jacob Ls Bellmund1,2,3, Lorena Deuker4, Christian F Doeller1,2

  • 1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.

Elife
|August 7, 2019
PubMed
Summary
This summary is machine-generated.

The anterior-lateral entorhinal cortex (alEC) represents temporal event structures crucial for episodic memory. This region

Keywords:
entorhinal cortexepisodic memoryfMRIhumanmemoryneurosciencetimevirtual reality

More Related Videos

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
17:13

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

Published on: October 22, 2017

17.8K
Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
09:31

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

Published on: March 22, 2016

18.3K

Related Experiment Videos

Last Updated: Jan 21, 2026

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

2.8K
Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain
17:13

Exploring Deep Space - Uncovering the Anatomy of Periventricular Structures to Reveal the Lateral Ventricles of the Human Brain

Published on: October 22, 2017

17.8K
Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites
09:31

Amplification, Next-generation Sequencing, and Genomic DNA Mapping of Retroviral Integration Sites

Published on: March 22, 2016

18.3K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Memory Research

Background:

  • Episodic memory relies on remembering event sequences.
  • The hippocampal-entorhinal region supports episodic memory.
  • Previous research mapped spatial and temporal distances in the hippocampus, but entorhinal content was unclear.

Purpose of the Study:

  • To investigate the content of mnemonic representations in the anterior-lateral entorhinal cortex (alEC).
  • To determine if alEC representations reflect temporal event structure.
  • To understand the role of alEC in temporal aspects of episodic memory.

Main Methods:

  • fMRI study using a virtual city navigation task.
  • Analysis of multi-voxel representations in the anterior-lateral entorhinal cortex (alEC).
  • Reconstruction of sequence structure and event timeline from entorhinal patterns.

Main Results:

  • Multi-voxel patterns in the alEC specifically reflect learned temporal event structure.
  • Holistic representations of sequence structure were reconstructed from alEC activity.
  • Findings align with rodent lateral entorhinal cortex temporal signals and human alEC activation during temporal recall.

Conclusions:

  • The anterior-lateral entorhinal cortex (alEC) represents temporal structure for episodic memory.
  • This provides evidence for alEC's role in encoding and retrieving the timeline of events.
  • Supports a conserved role of the lateral entorhinal cortex in temporal representation across species.