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Updated: Jul 26, 2026

Paradigms for Behavioral Assessment in Drosophila Model of Autism Spectrum Disorder
Published on: September 6, 2024
Molecular biology of autism's etiology - An alternative mechanism
Gary Steinman1, David Mankuta1
1Department of Obstetrics & Gynecology, Hadassah Hospital/Hebrew University, Ein Kerem, Jerusalem 12000, Israel.
Abstract:
Autism is a neuropathologic condition believed to be the consequence of cerebral dysconnectivity. Hypomyelination of axons in brain nerve pathways parallels behavioral abnormalities characteristic of autism. The present discussion will examine the functional association of insulin-like growth factor-1 (IGF1) to neo-neuron myelination, especially in autistic children. These structural defects apparently correlate with a reduced level of circulating IGF. In addition, the potential connection of single nucleotide polymorphism to the etiology of autism is considered. Pharmaceutical and nutritional supplements that may enhance IGF1 to reduce the incidence of autism are proposed.
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