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An evolutionary tree for invertebrate globin sequences.

M Goodman1, J Pedwaydon, J Czelusniak

  • 1Department of Anatomy, Wayne State University School of Medicine, Detroit, Michigan 48201.

Journal of Molecular Evolution
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study constructed a phylogenetic tree of 245 globin sequences, revealing five distinct clades: plants, annelids, arthropods, molluscs, and vertebrates. The findings support hypotheses on metazoan hemoglobin evolution and its independent derivation in certain lineages.

Area of Science:

  • Evolutionary Biology
  • Molecular Phylogenetics
  • Biochemistry

Background:

  • Globins are essential proteins involved in oxygen transport and storage across diverse taxa.
  • Understanding globin evolution provides insights into the evolutionary history of life.
  • Phylogenetic analysis of globin sequences can illuminate deep evolutionary relationships.

Purpose of the Study:

  • To construct a comprehensive phylogenetic tree of globin sequences from plants, invertebrates, and vertebrates.
  • To date key evolutionary divergences using molecular clock methods and fossil records.
  • To test hypotheses regarding the primitive form of metazoan hemoglobin and the evolution of extracellular hemoglobins.

Main Methods:

  • Construction of a phylogenetic tree using 245 globin amino acid sequences.

Related Experiment Videos

  • Alignment of sequences using the parsimony principle and construction of a minimum mutational distance matrix.
  • Application of clustering and branch-swapping algorithms to identify the most parsimonious tree.
  • Dating of evolutionary divergences using local molecular clock calculations and fossil data.

    • Main Results:

    • The phylogenetic tree comprised five distinct clades: plants, annelids, arthropods, molluscs, and vertebrates.
    • Key evolutionary splits were dated, including the ancestral metazoan lineage (680 Mya), vertebrate origin (510 Mya), and chondrichthyan-osteichthyan separation (425 Mya).
    • The maximum parsimony tree supported the hypothesis of a primitive monomeric metazoan hemoglobin and independent evolution of multisubunit extracellular hemoglobins in annelids and arthropods.

    Conclusions:

    • Phylogenetic analysis of globin sequences accurately reflects major taxonomic groups.
    • The evolutionary history of globins is consistent with paleontological data.
    • Multisubunit extracellular hemoglobins in Annelida and Arthropoda are likely independently evolved structures.