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Prebiotics and probiotics in atopic dermatitis
Emilia Rusu1, Georgiana Enache1,2, Raluca Cursaru1
1Department 2 Infectious Diseases, Epidemiology, Microbiology, Parasitology, Virology, Diabetes, Endocrinology, 'Carol Davila' University of Medicine and Farmacy, 010458 Bucharest, Romania.
Experimental and Therapeutic Medicine
|August 7, 2019
Summary
Probiotics and prebiotics show promise for atopic dermatitis. Supplementation, particularly probiotics for at least 8 weeks, may improve symptom severity by enhancing gut health and immune response.
Area of Science:
- Immunology
- Microbiome research
- Dermatology
Background:
- Atopic dermatitis is linked to increased intestinal permeability and reduced skin microbiome diversity.
- Prebiotics and probiotics are increasingly studied for their therapeutic potential in managing inflammatory skin conditions.
Purpose of the Study:
- To review current literature on the benefits of prebiotics and probiotics for atopic dermatitis.
- To analyze treatment effects across different age groups and identify knowledge gaps.
Main Methods:
- Systematic literature search of PubMed, Scopus, Embase, and Cochrane databases until June 5, 2018.
- Keywords included 'prebiotic', 'probiotic', 'atopic dermatitis', 'Severity Scoring of Atopic Dermatitis (SCORAD)'.
Main Results:
- Probiotics may improve atopic dermatitis severity by modulating the gut microbiome and immune system, enhancing intestinal barrier function.
- Evidence suggests benefits across infants, children, adults, and during pregnancy/lactation, with most trials supporting at least 8 weeks of probiotic use.
Conclusions:
- Probiotic and prebiotic interventions show potential for atopic dermatitis management.
- Further research is needed on optimal dosing, duration, and personalized treatment strategies based on individual microbiome profiles.
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