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Cost-effectiveness of treating hepatitis C in Seychelles
Naomi Joan Faray Adeline1, Claudia Geue2, Mohsen Rezaei Hermami3
1Communicable Disease Control Unit, Ministry of Health Seychelles, Victoria, Seychelles.
The Pan African Medical Journal
|August 7, 2019
Summary
Treating hepatitis C in Seychelles with Harvoni is cost-saving, even for all patients regardless of drug injection status. This approach offers a cost-effective solution for managing the disease and improving public health outcomes.
Area of Science:
- Hepatology
- Health Economics
- Public Health Policy
Background:
- Hepatitis C (HCV) affects 80 million globally, causing 700,000 deaths annually.
- Seychelles reported 777 HCV cases (2002-2016), with treatment limitations until mid-2016.
- Harvoni (sofosbuvir/ledipasvir) treatment is now available, with prior restrictions on drug injection status.
Purpose of the Study:
- To determine the cost-effectiveness of treating all HCV cases in Seychelles with Harvoni.
- To compare the cost-effectiveness of Harvoni treatment versus no treatment.
- To evaluate the economic impact from the Seychelles government's perspective.
Main Methods:
- An economic model populated with literature data was used.
- A Markov model with a lifetime horizon was developed.
- Cost-effectiveness was analyzed from a payer's perspective, calculating Incremental Cost-Effectiveness Ratios (ICERs).
Main Results:
- Harvoni treatment was found to be cost-saving for the Seychelles HCV cohort compared to no treatment.
- The overall ICER was €753.65/QALY, with gender-specific ICERs of €783.74/QALY (male) and €635.20/QALY (female).
- Acceptability curves indicated Harvoni is the most cost-effective option across various thresholds.
Conclusions:
- Treating hepatitis C cases in Seychelles with Harvoni is a cost-saving strategy.
- A comprehensive treatment program for all HCV cases, irrespective of drug injection status, is recommended.
- Implementing universal Harvoni treatment can lead to significant economic benefits and improved health outcomes.
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