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Precision medicine in adult and pediatric obesity: a clinical perspective

Eric M Bomberg1, Justin R Ryder2, Richard C Brundage3

  • 1Department of Pediatrics and Center for Pediatric Obesity Medicine, University of Minnesota, Minneapolis, 717 Delaware Street SE, Room 371, Minneapolis, MN 55414, USA.

Therapeutic Advances in Endocrinology and Metabolism
|August 7, 2019
PubMed

Insights

Individual characteristics significantly impact obesity treatment success, leading to varied weight loss outcomes. Precision medicine aims to tailor therapies for better results by considering personal factors.

Area of Science:

  • Obesity research
  • Precision medicine
  • Personalized treatment strategies

Background:

  • Obesity is a complex disease with diverse biopsychosocial determinants.
  • Significant heterogeneity exists in individual responses to obesity interventions.
  • Understanding person-specific factors is crucial for effective obesity management.

Purpose of the Study:

  • To review the role of person-specific characteristics in obesity treatment response.
  • To explore the application of precision medicine in obesity care.
  • To identify gaps in understanding and propose solutions for targeted obesity therapies.

Main Methods:

  • Literature review of biopsychosocial determinants of obesity.
  • Analysis of studies on person-specific predictors of weight loss.
  • Examination of evidence for various obesity interventions (lifestyle, pharmacotherapy, surgery, devices).

Main Results:

  • Person-specific characteristics significantly influence weight loss outcomes across different obesity treatments.
  • Genetics, environment, and lifestyle are key factors in treatment response variability.
  • Current obesity interventions show suboptimal results in some individuals due to a lack of personalization.

Conclusions:

  • Personalized approaches, guided by precision medicine principles, are essential for optimizing obesity treatment.
  • Further research is needed to elucidate the complex interplay of factors driving obesity and treatment response.
  • Developing targeted obesity therapies requires a deeper understanding of individual variability.
Keywords:
anti-obesity agentsbariatric surgeryobesityobesity etiologyprecision medicineweight loss

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