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Testosterone Supplementation and Cognitive Functioning in Men-A Systematic Review and Meta-Analysis.
Cecilie R Buskbjerg1, Claus H Gravholt2,3, Helene R Dalby4
1Unit for Psychooncology and Health Psychology, Department of Oncology, Aarhus University Hospital and Department of Psychology and Behavioral Science, Aarhus University, Aarhus, Denmark.
Journal of the Endocrine Society
|August 7, 2019
Summary
Testosterone supplementation (TS) shows no significant cognitive benefits for men with normal testosterone levels. Further research is needed to determine effects in clinically hypogonadal men.
Area of Science:
- Endocrinology
- Neuroscience
- Psychology
Background:
- Testosterone supplementation (TS) is widely believed to influence male cognitive function.
- However, existing research presents conflicting findings, necessitating a comprehensive review.
Purpose of the Study:
- To systematically review and meta-analyze randomized controlled trials (RCTs) investigating the effects of TS on cognitive functioning in men.
- To explore potential moderators of these effects.
Main Methods:
- A systematic search of major electronic databases (PubMed, PsycINFO, Web of Science, etc.) was conducted.
- Eligibility criteria included male adults, TS intervention, placebo comparison, and standardized neuropsychological test outcomes.
- Twenty-one RCTs (23 studies) involving men with normal testosterone levels were included in the meta-analysis.
Main Results:
- Overall cognitive functioning showed a non-significant small improvement (Hedges g = 0.09, P = 0.108) with TS.
- Publication bias adjustment reduced the effect size to near zero (g = 0.04).
- No statistically significant effects were observed for individual cognitive domains.
Conclusions:
- Current evidence suggests TS does not yield clinically relevant cognitive benefits for men with testosterone levels within the normal range.
- The cognitive effects of TS in clinically hypogonadal men require further investigation.
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