A case of pseudohypoparathyroidism type 1 associated with gonadotropin resistance and hypercalcitoninaemia

A case of a thirty-eight year old man with pseudohypoparathyroidism (PHP) type 1 associated with gonadotropin resistance and hypercalcitoninaemia was reported. The basal levels of the luteinizing hormone and follicle-stimulating hormone were elevated, and the responses to the luteinizing hormone-releasing hormone were exaggerated. The basal level of testosterone was normal, but the response to human chorionic gonadotropin was blunted. The serum calcitonin level was high, and hyper-responsiveness was observed by pentagastrin administration. From these results, it was suggested that partial testicular resistance to gonadotropin and the possibility of resistance to calcitonin were present in our case.