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Updated: Jan 21, 2026

Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
Base-promoted domino radical cyclization of 1,6-enynes
Le-Han Gao1, Jun-Yao Zhang1, Si-Zhe Song1
1School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China. weiwenting@nbu.edu.cn.
Abstract:
A good regioselective, high atom-economical and transition-metal-free method for the synthesis of α-functionalized ether derivatives via the domino radical cyclization of 1,6-enynes is described. A series of α-functionalized ether derivatives could be easily obtained in good yields with wide functional group tolerance by using less toxic and inexpensive Cs2CO3 as the base. The control experiment results show that the reaction involves a radical process. This strategy provides a regioselective way toward the formation of dual C-C bonds in one step.
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