Putative Trace-Amine Associated Receptor 5 (TAAR5) Agonist α-NETA Increases Electrocorticogram Gamma-Rhythm in Freely
D R Belov1, E V Efimova2, Z S Fesenko2
1Department of Higher Nervous Activity and Psychophysiology, Saint Petersburg State University, Universitetskaya nab., 7-9, Saint Petersburg, 199034, Russia. dmbelov64@mail.ru.
Cellular and Molecular Neurobiology
|August 7, 2019
Summary
Trace Amine-Associated Receptor 5 (TAAR5) activation by α-NETA alters dopamine levels and brain gamma rhythms. These changes mimic cognitive deficits seen in schizophrenia, suggesting TAAR5
Area of Science:
- Neuroscience
- Pharmacology
- Cognitive Science
Background:
- Cortical gamma rhythm is crucial for inter-brain area communication, implicated in cognitive dysfunction.
- Trace amines, including those acting on Trace Amine-Associated Receptor 5 (TAAR5), modulate classical monoamine systems like dopamine.
- Understanding TAAR5's role is vital for exploring novel therapeutic targets for cognitive disorders.
Purpose of the Study:
- To investigate the modulatory influence of the trace amine receptor TAAR5 on the dopamine system.
- To assess the impact of a putative TAAR5 agonist (α-NETA) on electrocorticogram (ECoG) spectral power and synchronization in the gamma frequency range.
- To explore the potential role of TAAR5 in cognitive functions and brain pathologies.
Main Methods:
- High-Performance Liquid Chromatography (HPLC) was used to measure dopamine and its metabolites in mouse striatum after α-NETA administration.
- Electrocorticogram (ECoG) recordings were performed in rats to analyze spectral power and spatial synchronization of brain rhythms (delta, theta, gamma) following α-NETA administration.
- Multichannel recordings facilitated the analysis of spatial synchronization changes in gamma and theta oscillations.
Main Results:
- Administration of α-NETA significantly modulated the dopaminergic system, altering dopamine turnover rates in the striatum.
- Significant changes in the rat ECoG spectrum were observed, including increased power in delta (1 Hz), theta (7 Hz), and gamma (40-50 Hz) rhythms.
- A decrease in spatial synchronization of gamma oscillations (40-50 Hz) and an increase in theta oscillations (7 Hz) were detected post-α-NETA administration.
Conclusions:
- The putative TAAR5 agonist α-NETA modulates striatal dopamine transmission.
- α-NETA induces significant alterations in brain gamma rhythm activity, mirroring deficits observed in schizophrenia.
- These findings suggest a potential role for TAAR5 in modulating cognitive functions relevant to brain pathologies.
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