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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
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Sickle cell disease: a review for the internist

Valeria Maria Pinto1, Manuela Balocco1, Sabrina Quintino1

  • 1Centro della Microcitemia E Delle Anemie Congenite Ente Ospedaliero Ospedali Galliera, Via Volta 6, 16128, Genoa, Italy.

Internal and Emergency Medicine
|August 7, 2019
PubMed

Insights

Sickle cell disease (SCD), a global health issue, causes severe complications. This review details acute and chronic manifestations and management for internists and emergency specialists.

Area of Science:

  • Hematology
  • Genetics
  • Public Health

Background:

  • Sickle cell disease (SCD) is a significant global hemoglobinopathy.
  • It is a monogenic, multisystem disorder with substantial morbidity and mortality.
  • Key pathophysiological features include vaso-occlusion, hemolytic anemia, and vasculopathy.

Purpose of the Study:

  • To review the acute and chronic clinical manifestations of SCD.
  • To discuss the current management strategies for SCD.
  • To provide guidance for internists and emergency specialists managing SCD patients.

Main Methods:

  • This is a review article.
  • It synthesizes current knowledge on SCD pathophysiology and clinical care.
  • Focuses on time-dependent acute and chronic complications.

Main Results:

  • SCD presents with diverse acute and chronic complications.
  • Effective management requires understanding of pathophysiology.
  • Internists and emergency specialists play a crucial role in patient care.

Conclusions:

  • SCD is a complex global health challenge requiring comprehensive management.
  • Awareness of acute and chronic issues is vital for clinicians.
  • This review supports healthcare professionals in managing SCD patients effectively.

Keywords:
HemoglobinopathySCD chronic complicationsSCD managementSickle cell crisesSickle cell diseaseTime-dependent

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