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Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
Cerebral glucose metabolism differs according to future weight change
Jeong Mi Kim1, Minhee Jang1, Eun Heui Kim1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.
Brain glucose metabolism may predict future weight changes. Individuals gaining weight showed reduced metabolism in the left cerebellum, while weight change correlated with metabolism in the right insula and caudate nucleus.
Area of Science:
- Neuroscience
- Metabolism
- Brain Imaging
Background:
- The brain significantly influences appetite and eating behavior.
- Understanding long-term brain effects on weight is crucial for metabolic health.
- The Alzheimer's Disease Neuroimaging Initiative (ADNI) database offers valuable longitudinal data.
Purpose of the Study:
- To identify brain regions associated with long-term eating behavior and weight changes.
- To investigate the relationship between brain glucose metabolism and future weight fluctuations.
- To explore potential predictive markers for weight change.
Main Methods:
- Utilized data from 96 cognitively normal subjects from the ADNI database, followed for 36 months.
- Measured weight changes and analyzed brain glucose metabolism using 18F-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET).
- Employed Statistical Parametric Mapping 12 for image analysis to correlate brain metabolism with weight changes.
Main Results:
- Subjects with future weight gain exhibited hypometabolism in the left cerebellum compared to those with stable weight or weight loss.
- A positive association was observed between percentage weight change and brain metabolism in the right insula and right caudate nucleus.
- Brain glucose metabolism patterns appeared to precede measurable weight changes.
Conclusions:
- Left cerebellar hypometabolism may be linked to future weight gain.
- Right insula and right caudate nucleus metabolism are positively associated with weight change.
- Brain glucose metabolism could serve as an early indicator of future weight alterations.
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