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Comparison between apomorphine and amphetamine-induced rotational behaviour in rats with a unilateral nigrostriatal
1Laboratori de Neuropsicofarmacologia, Hospital de Sant Pau, Barcelona, Spain.
Neuropharmacology
|June 1, 1988
Abstract:
Apomorphine and amphetamine-induced rotational behaviour in 310 rats with a unilateral 6-OHDA nigrostriatal pathway lesion has been studied. Animals presenting an apomorphine-induced contralateral rotation with a "two-peak" pattern, showed a greater number of contralateral turns induced by apomorphine and fewer ipsilateral turns induced by amphetamine than rats without this pattern. In addition, we have not found any correlation between apomorphine and amphetamine-induced turning behaviour.