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Updated: Jan 21, 2026
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Characterizing Exon Skipping Efficiency in DMD Patient Samples in Clinical Trials of Antisense Oligonucleotides
Published on: May 7, 2020
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Clinical trial endpoints for patients with gliomas
Jennie W Taylor1,2, Annette M Molinaro1,3, Nicholas Butowski1
1Department of Neurological Surgery, University of California San Francisco, San Francisco, California (J.W.T., A.M.M., N.B., M.P.).
Neuro-Oncology Practice
|August 7, 2019
Summary
Malignant gliomas are complex brain tumors with few effective treatments. This study examines unresolved issues in clinical trial endpoints for primary glioma patients, focusing on new trial designs.
Area of Science:
- Neuro-oncology
- Genomics
- Clinical Trial Design
Background:
- Malignant gliomas are molecularly diverse and challenging to treat.
- Decades of research have yielded limited therapeutic advancements for these brain tumors.
Purpose of the Study:
- To address unresolved issues in clinical trial endpoints for primary glioma.
- To discuss novel approaches in clinical trial design for malignant glioma.
Main Methods:
- Review of current neuroimaging criteria.
- Analysis of genomic profiles and their link to survival outcomes.
- Discussion of potential new endpoints in clinical trial design.
Main Results:
- Genomic profiling reveals tumor subsets correlating with survival.
- Refined neuroimaging criteria may improve trial stratification.
- New endpoints are needed to better evaluate therapeutic efficacy.
Conclusions:
- Addressing endpoint challenges is crucial for advancing glioma treatment.
- Integrating genomic and imaging data can inform future trial designs.
- Further research is needed to optimize clinical trial strategies for malignant gliomas.
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