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Chemotherapy and diffuse low-grade gliomas: a survey within the European Low-Grade Glioma Network

Amélie Darlix1, Emmanuel Mandonnet2, Christian F Freyschlag3

  • 1Department of Medical Oncology, Institut du Cancer de Montpellier, University of Montpellier, France.

Neuro-Oncology Practice
|August 7, 2019
PubMed
Abstract

Insights

Management of diffuse low-grade gliomas (DLGG) shows significant variation. Chemotherapy use, particularly temozolomide, is common post-surgery, but optimal strategies remain unclear, necessitating further research.

Area of Science:

  • Neuro-oncology
  • Clinical trial design
  • Cancer treatment strategies

Background:

  • Diffuse low-grade gliomas (DLGG) are rare, incurable brain tumors.
  • Maximal safe surgical resection is the primary treatment.
  • Post-operative management, including chemotherapy and radiation, is debated.

Purpose of the Study:

  • To assess current management practices for DLGG patients.
  • To evaluate the heterogeneity in chemotherapy use among expert centers.
  • To identify areas for future research in DLGG treatment.

Main Methods:

  • An online survey was distributed to 28 European Low-Grade Glioma Network (ELGGN) centers in May 2015.
  • The survey comprised 40 questions focused on chemotherapy administration in DLGG.
  • Data collection targeted expert opinions on treatment modalities.

Main Results:

  • Significant practice heterogeneity observed in DLGG initial management and chemotherapy use.
  • Radiation therapy with procarbazine, CCNU, and vincristine is not universally adopted post-surgery.
  • Temozolomide is widely used as first-line treatment or at progression for high-risk DLGG.

Conclusions:

  • Current DLGG management highlights unanswered questions regarding postoperative strategy and chemotherapy.
  • The ELGGN presents a strong potential for patient recruitment in future studies.
  • Further research is needed to establish optimal treatment guidelines for DLGG.
Keywords:
PCVchemotherapyclinical practicediffuse low-grade gliomatemozolomide

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