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Pulmonary Function Tests01:25

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Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
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Early cognitive function tests predict early progression in glioblastoma.

Soon-Tae Lee1, Chul-Kee Park1, Jin Wook Kim1

  • 1Department of Neurology, Seoul National University Hospital, Seoul, Korea (S.-T.L., H.L., J.-A.L., K.-M.L.); Department of Neurosurgery, Seoul National University Hospital, Seoul, Korea (C.-K.P., J.W.K., M.-J.P.); Department of Radiology, Seoul National University Hospital, Seoul, Korea (S.H.C.); Division of Medical Oncology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea (T.M.K., S.-H.L.); Department of Pathology, Seoul National University Hospital, Seoul, Korea (S.-H.P.); Department of Radiation Oncology,Seoul National University Hospital, Seoul, Korea (I.H.K.).

Neuro-Oncology Practice
|August 7, 2019
PubMed
Summary

Preoperative cognitive tests, specifically the Trail Making Test B, can predict early glioblastoma progression. Better performance on TMT-B indicates a better early prognosis for glioblastoma patients.

Keywords:
6-month progression-free survivalcognitive function testglioblastomatrail making test

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Area of Science:

  • Neuro-oncology
  • Cognitive Neuroscience
  • Clinical Neurology

Background:

  • Early glioblastoma progression impedes standard chemoradiation.
  • Cognitive function is a known prognostic factor in glioblastoma.

Purpose of the Study:

  • To evaluate the utility of preoperative cognitive function tests in predicting early glioblastoma progression.
  • To identify specific cognitive tests that can serve as reliable prognostic indicators.

Main Methods:

  • 126 glioma patients underwent preoperative cognitive tests (MMSE, digit span, COWAT, TMT A/B/C, Stroop).
  • Glioblastoma patients received standard radiation and temozolomide.
  • Retrospective analysis of 6-month progression-free survival (PFS-6).

Main Results:

  • 50 glioblastoma patients were analyzed for PFS-6; 68% achieved it.
  • Patients achieving PFS-6 showed better performance on Trail Making Test A (TMT-A) and TMT-B.
  • Multivariate analysis identified TMT-B as the sole independent predictor of PFS-6.

Conclusions:

  • Preoperative Trail Making Tests (TMTs) are valuable for rapid early prognosis assessment in glioblastoma.
  • TMT-B performance is a significant independent predictor of early progression in glioblastoma.