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Updated: Jan 21, 2026
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An Orthotopic Resectional Mouse Model of Pancreatic Cancer
Published on: September 24, 2020
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Screening for Pancreatic Cancer: US Preventive Services Task Force Reaffirmation Recommendation Statement
, Douglas K Owens1,2, Karina W Davidson3
1Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
JAMA
|August 7, 2019
Summary
Screening for pancreatic cancer in asymptomatic adults is not recommended. Evidence shows potential harms outweigh limited benefits, with no improvement in mortality or morbidity.
Area of Science:
- Oncology
- Preventive Medicine
- Clinical Guidelines
Background:
- Pancreatic cancer has a poor prognosis and is a leading cause of cancer death in the US.
- Its incidence is increasing, potentially making it the second leading cause of cancer death.
Purpose of the Study:
- To update the US Preventive Services Task Force (USPSTF) recommendation on pancreatic cancer screening.
- Evaluate benefits and harms of screening and treating screen-detected pancreatic cancer.
Main Methods:
- Systematic review of evidence on pancreatic cancer screening.
- Assessed diagnostic accuracy of screening tests.
- Evaluated benefits and harms of treatment for screen-detected cancer.
Main Results:
- No evidence found that screening improves disease-specific or all-cause mortality.
- Benefits of screening in asymptomatic adults are small.
- Harms of screening and treatment are at least moderate.
Conclusions:
- Potential benefits of screening do not outweigh potential harms.
- USPSTF recommends against screening for pancreatic cancer in asymptomatic adults.
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