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Updated: Jan 21, 2026
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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
Published on: October 8, 2021
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Rigidity-Dependent Placental Cells Uptake of Silk-Based Microcapsules
Xiaoqin Li1,2, Hongbo Tang3, Xiaoli Huang4
1College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang, 443002, China.
Macromolecular Bioscience
|August 7, 2019
Summary
Silk microcapsules
Area of Science:
- Biomaterials Science
- Cell Biology
- Biomedical Engineering
Background:
- Polymeric microcapsules are increasingly used in biomedical applications.
- Cell-material interactions depend on cell type and material elasticity.
- Silk-based microcapsules offer tunable mechanical properties.
Purpose of the Study:
- To investigate the cellular uptake of silk-based microcapsules by placental cells.
- To determine how microcapsule elasticity influences uptake by BeWo b30 cells.
- To explore the role of microvilli behavior in particle uptake.
Main Methods:
- Layer-by-layer assembly was used to synthesize silk microcapsules with varying mechanical features.
- The uptake of these microcapsules by BeWo b30 placental cells was quantified.
- Microvilli interactions with microcapsules of different elastic moduli were observed.
Main Results:
- Cellular uptake of silk microcapsules increased with higher elastic modulus.
- Microvilli exhibited distinct behaviors, such as grabbing (rigid) or random touching (soft), towards microcapsules.
- These microvillar behaviors influenced the overall uptake efficiency.
Conclusions:
- Microcapsule elasticity significantly impacts cellular uptake by placental cells.
- Microvilli's mechanical interaction with particles is crucial for understanding cellular uptake mechanisms.
- This research offers insights into cell-particle interactions, particularly relevant to reproductive system applications.
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