Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Law of Segregation01:49

Law of Segregation

77.6K
When crossing pea plants, Mendel noticed that one of the parental traits would sometimes disappear in the first generation of offspring, called the F1 generation, and could reappear in the next generation (F2). He concluded that one of the traits must be dominant over the other, thereby causing masking of one trait in the F1 generation. When he crossed the F1 plants, he found that 75% of the offspring in the F2 generation had the dominant phenotype, while 25% had the recessive phenotype.
77.6K
Protein Networks02:26

Protein Networks

4.5K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.5K
Segregation in Fresh Concrete01:16

Segregation in Fresh Concrete

556
Segregation in fresh concrete is a phenomenon where the components of the concrete mix separate, leading to uneven distribution and compromised structural integrity. This separation typically occurs when concrete is subjected to excessive horizontal movement within forms, or when it is dropped from considerable heights or forced through narrow, winding paths. As a result, heavier coarse aggregate particles settle at the bottom, while lighter, finer materials such as cement and water rise to the...
556
Actin Treadmilling01:18

Actin Treadmilling

9.6K
Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...
9.6K
Energy to Drive Translocation01:37

Energy to Drive Translocation

2.7K
Mitochondrial protein import is powered by two distinct energy sources: ATP hydrolysis and electrochemical potential across the inner membrane. Newly synthesized precursors are bound by cytosolic chaperones of the Hsp70 family, which guide them to the import receptors on the mitochondrial surface. Utilizing the energy of ATP hydrolysis, Hsp70 chaperones transfer these precursors to the TOM receptors on the mitochondrial outer membrane.
Generally, polypeptides are unfolded by two distinct...
2.7K
Bulk Modulus01:21

Bulk Modulus

736
The bulk modulus is a scientific term used to describe a material's resistance to uniform compression. It is the proportionality constant that links a change in pressure to the resulting relative volume change.
736

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanical strain focusing at topological defect sites in regenerating Hydra.

Development (Cambridge, England)·2025
Same author

Effective membrane tension: A long-range integrator of cellular dynamics.

Cell·2023
Same author

Plasticity of body axis polarity in Hydra regeneration under constraints.

Scientific reports·2022
Same author

Canalized Morphogenesis Driven by Inherited Tissue Asymmetries in <i>Hydra</i> Regeneration.

Genes·2022
Same author

Cytoskeletal symmetry breaking in animal cells.

Current opinion in cell biology·2021
Same author

Mechanical Patterning in Animal Morphogenesis.

Annual review of cell and developmental biology·2021

Related Experiment Video

Updated: Jan 21, 2026

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops
06:48

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

877

Cellular Organization: Bulk Actin Network Flows Drive Ooplasm Segregation.

Niv Ierushalmi1, Kinneret Keren2

  • 1Department of Physics, Technion - Israel Institute of Technology, Haifa 32000, Israel.

Current Biology : CB
|August 7, 2019
PubMed
Summary

Cytoplasmic actin networks, not the cortex, drive ooplasm segregation in zebrafish oocytes. Contracting actin pulls ooplasm towards the animal pole while actin comet tails push yolk granules away.

More Related Videos

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
07:15

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

4.9K
Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons
10:13

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons

Published on: February 10, 2016

12.7K

Related Experiment Videos

Last Updated: Jan 21, 2026

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops
06:48

Tuning the Contractility and Deformation Modes of Active Actin-Based Assemblies In Vitro: From Two-Dimensional Active Networks to Liquid Crystal Drops

Published on: July 11, 2025

877
Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research
07:15

Tactile Vibrating Toolkit and Driving Simulation Platform for Driving-Related Research

Published on: December 18, 2020

4.9K
Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons
10:13

Quantification of Filamentous Actin F-actin Puncta in Rat Cortical Neurons

Published on: February 10, 2016

12.7K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Cytoskeletal Dynamics

Background:

  • Oocyte maturation involves the segregation of cytoplasmic components.
  • The precise mechanisms governing ooplasm segregation in zebrafish oocytes remain incompletely understood.
  • Previous hypotheses often focused on cortical actin dynamics.

Purpose of the Study:

  • To elucidate the primary drivers of ooplasm segregation in zebrafish oocytes.
  • To differentiate the roles of bulk cytoplasmic versus cortical actin networks in this process.

Main Methods:

  • Live imaging of fluorescently labeled actin and yolk granules in zebrafish oocytes.
  • Perturbation experiments to assess the function of actin networks.

Main Results:

  • Actin networks within the bulk cytoplasm, not the cell cortex, are the main force driving ooplasm segregation.
  • A contracting cytoplasmic actin network actively drags the ooplasm towards the animal pole.
  • Actin-based 'comet tails' propel yolk granules away from the ooplasm, ensuring their segregation.

Conclusions:

  • Bulk cytoplasmic actin networks are essential for ooplasm segregation in zebrafish oocytes.
  • The coordinated action of cytoplasmic actin contraction and comet tail propulsion dictates the final localization of ooplasmic components and yolk granules.