Related Experiment Video

Updated: Jan 21, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

12.6K

Low-Grade Albuminuria Is Associated with Left Ventricular Hypertrophy and Diastolic Dysfunction in Patients with

Tingjun Wang1, Hongbin Zhong1, Guili Lian1

  • 1Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Kidney & Blood Pressure Research
|August 7, 2019
PubMed

Insights

Low-grade albuminuria, even within normal levels, is linked to heart damage in hypertensive patients. This association is particularly notable in younger individuals and those with shorter hypertension duration.

Area of Science:

  • Cardiology
  • Nephrology
  • Hypertension Research

Background:

  • Microalbuminuria is a known cardiovascular risk factor in hypertension.
  • The link between low-grade albuminuria and hypertension-related organ damage remains unclear.
  • Left ventricular hypertrophy (LVH) and diastolic dysfunction are key indicators of hypertensive heart disease.

Purpose of the Study:

  • To investigate the association between low-grade albuminuria and left ventricular hypertrophy (LVH).
  • To examine the relationship between low-grade albuminuria and left ventricular diastolic dysfunction in hypertensive patients.

Main Methods:

  • A cross-sectional study of 870 hypertensive patients.
  • Albuminuria assessed using urinary albumin to creatinine ratio (UACR).
  • Low-grade albuminuria defined as the highest tertile within normal UACR levels.

Main Results:

  • Low-grade albuminuria was independently associated with LVH and LV diastolic dysfunction.
  • Patients with the highest tertile of normal albuminuria showed increased odds of LVH and diastolic dysfunction.
  • The association persisted in specific subgroups, including females and those younger than 70.

Conclusions:

  • Low-grade albuminuria is associated with cardiac structural and functional changes in hypertensive patients.
  • This association is significant even at albuminuria levels below the microalbuminuria threshold.
  • Early detection and management of low-grade albuminuria may be crucial for preventing cardiovascular complications in hypertension.
Abstract

Keywords:
HypertensionLeft ventricular diastolic dysfunctionLeft ventricular hypertrophyLow-grade albuminuria

More Related Videos

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse06:04

Echocardiographic Measurement of Right Ventricular Diastolic Parameters in Mouse

Published on: April 27, 2019

8.1K
Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension10:03

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension

Published on: June 27, 2025

740

Related Concept Videos

Graded Potential01:19

Graded Potential

Graded potentials are localized fluctuations in the cell membrane's electrical charge, commonly found in the dendrites of neurons. The magnitude of these potential changes depends on the strength of the initiating stimulus. In a membrane at its resting potential, a graded potential signifies a voltage shift either above -70 mV or below -70 mV.
Graded potentials fall into two categories: depolarizing and hyperpolarizing. Depolarizing graded potentials typically occur when sodium (Na+) or...
6.9K
Types of Aggregate Grading01:15

Types of Aggregate Grading

Aggregate grading is crucial in economically obtaining a concrete mix with adequate strength, reasonable workability, and minimal segregation. There are four types of aggregate gradation: well-graded, uniformly (or one-sized) graded, gap-graded, and open-graded.
Well-graded aggregates include a complete range of necessary size fractions that fit together to create a dense matrix with minimal voids, represented by a smooth, continuous gradation curve. This type of grading ensures good...
1.4K
Hypertension I: Introduction01:28

Hypertension I: Introduction

Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
758
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
839
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.
377
Sieve Analysis and Grading Curves01:19

Sieve Analysis and Grading Curves

Sieve analysis is a method used to determine the particle size distribution of aggregate materials. This process involves the following steps:
929