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Visit-to-Visit Variability in Total Cholesterol Correlates with the Progression of Renal Function Decline in a

Yuqin Yan1, Yuqin Huang1, Dan Zhou1

  • 1Department of Cardiology, Guangdong Cardiovascular Institute, Hypertension Research Laboratory, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, South China University of Technology School of Medicine, Guangzhou, China.

Kidney & Blood Pressure Research
|August 7, 2019
PubMed

Insights

High cholesterol variability predicts kidney decline in hypertensive adults. Increased total cholesterol (TC) variability independently raises the risk of worsening kidney function, highlighting its importance in managing hypertension.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Syndrome

Background:

  • Cholesterol variability is a known risk factor for cardiovascular and cerebrovascular events.
  • Understanding its impact on kidney function is crucial for comprehensive patient management.

Purpose of the Study:

  • To examine the association between visit-to-visit variability in total cholesterol (TC) and kidney function decline.
  • To investigate this relationship in a Chinese community-based population with hypertension.

Main Methods:

  • Assessed intraindividual TC variability using standard deviation (SD), average successive variability (ASV), coefficient of variation (CV), and variability independent of the mean (VIM) in 6,465 hypertensive participants.
  • Defined renal function decline as a significant decrease in estimated glomerular filtration rate (eGFR) over a median follow-up of 27 months.

Main Results:

  • 13.5% of participants experienced renal function decline.
  • A 1-SD increase in TC variability (using SD) was associated with an 11% increased risk of renal function decline (HR = 1.11; p = 0.004).
  • This association remained significant after adjusting for baseline eGFR, mean TC levels, and lipid-lowering therapy, and was consistent across different variability measures.

Conclusions:

  • Visit-to-visit total cholesterol variability is an independent predictor of renal function decline in hypertensive individuals.
  • These findings underscore the importance of monitoring cholesterol variability in managing hypertensive patients to prevent kidney disease progression.
Abstract

Keywords:
CommunityHypertensive populationKidney functionTotal cholesterolVariability

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