Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

5.1K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
5.1K
Whole Body Regeneration01:33

Whole Body Regeneration

4.0K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
4.0K
Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Combinatorial Gene Control02:33

Combinatorial Gene Control

9.5K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.5K
Gene Flow02:39

Gene Flow

37.5K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
37.5K
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H01:13

meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H

6.6K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond plagiarism: emerging challenges in research integrity and editorial responsibility.

Journal of periodontal & implant science·2026
Same author

Cell-penetrating asymmetric siRNA targeting MyD88 suppresses inflammasome-driven ocular degeneration and angiogenesis.

Molecular therapy : the journal of the American Society of Gene Therapy·2026
Same author

Gingival phenotype modification using collagen matrix versus acellular allogenic dermal matrix: A comparative preclinical study.

Scientific reports·2026
Same author

A narrative review of preclinical animal models for bone regeneration: comparative and translational insights from rodents to large animals.

Journal of periodontal & implant science·2026
Same author

Personal PM<sub>2.5</sub> Exposure Using Time-Weighted Average Scenarios in the Seoul Metropolitan Area.

Toxics·2026
Same author

BMP9 promotes peri-implant osseointegration in beagle defects.

Journal of periodontal & implant science·2026

Related Experiment Video

Updated: Jan 21, 2026

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
10:23

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach

Published on: August 26, 2013

14.5K

BMP-2 Gene Delivery-Based Bone Regeneration in Dentistry.

Shin-Young Park1,2, Kyoung-Hwa Kim3, Sungtae Kim3

  • 1Program of Clinical Dental Education and Dental Research Institute, School of Dentistry, Seoul National University, Seoul 03080, Korea.

Pharmaceutics
|August 8, 2019
PubMed
Summary

Bone morphogenetic protein-2 (BMP-2) gene therapy offers a promising alternative to recombinant protein delivery for enhanced bone regeneration. This approach allows for sustained, localized BMP-2 production, potentially improving outcomes in dental implant treatments.

Keywords:
animal experimentationbone morphogenetic protein 2bone regenerationgene transfer technique

More Related Videos

Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.1K

Related Experiment Videos

Last Updated: Jan 21, 2026

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach
10:23

Covalent Binding of BMP-2 on Surfaces Using a Self-assembled Monolayer Approach

Published on: August 26, 2013

14.5K
Use of Human Perivascular Stem Cells for Bone Regeneration
07:05

Use of Human Perivascular Stem Cells for Bone Regeneration

Published on: May 25, 2012

22.0K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

12.1K

Area of Science:

  • Biomaterials and Regenerative Medicine
  • Gene Therapy
  • Oral and Maxillofacial Surgery

Background:

  • Bone morphogenetic protein-2 (BMP-2) is crucial for bone formation and is used in orthopedics and dentistry.
  • Recombinant human BMP-2 (rhBMP-2) has limitations, including high initial dosages and potential complications.
  • Determining an effective and safe rhBMP-2 dosage for bone regeneration remains a challenge.

Purpose of the Study:

  • To review the application of BMP-2 gene therapy for bone regeneration in oral and maxillofacial regions.
  • To discuss the advantages of BMP-2 gene delivery over protein delivery.
  • To explore future perspectives of BMP-2 gene therapy in dentistry.

Main Methods:

  • BMP-2 gene transfer induces in vivo synthesis and secretion of BMP-2 over extended periods.
  • Gene delivery offers advantages in dosage control and duration compared to protein administration.
  • Review of current literature on BMP-2 gene therapy in oral and maxillofacial bone regeneration.

Main Results:

  • BMP-2 gene delivery results in sustained, localized BMP-2 concentrations (nanograms per milliliter) for weeks to months.
  • This sustained delivery is advantageous for bone wound healing processes.
  • Ongoing clinical trials in dentistry are evaluating gene therapy applications.

Conclusions:

  • BMP-2 gene therapy presents a potentially safer and more effective alternative to rhBMP-2 for bone regeneration.
  • Overcoming safety concerns associated with viral vectors is key for clinical translation.
  • BMP-2 gene therapy holds significant promise for future dental and maxillofacial applications.