Related Experiment Video
Updated: Jan 21, 2026

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Magnetic mesoporous silica nanocomposites with binary metal oxides core-shell structure for the selective enrichment
Yilin Li1, Liangliang Liu1, Hao Wu2
1Department of Chemistry, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, 200433, China.
Abstract:
Developing an effective strategy for endogenous phosphopeptides enrichment and separation is necessary in phosphopeptidomics analysis due to the serious inference caused by chaotic biological environment. In this work, a size-exclusive magnetic binary metal mesoporous nanocomposites were synthesized to capture phosphorylated peptides for mass spectrometry analysis. The novel Fe3O4@TiO2-ZrO2@mSiO2 nanocomposites possessed the merits of ordered mesoporous channels, superparamagnetism and the integration of dual affinity of Zr-O and Ti-O. Compared with single-metal centered nanocomposites (Fe3O4@TiO2@mSiO2 and Fe3O4@ZrO2@mSiO2), Fe3O4@TiO2-ZrO2@mSiO2 showing much enhanced enrichment performance towards mono- and multi-phospho-peptides with better sensitivity. With all the advances, the Fe3O4@TiO2-ZrO2@mSiO2 was also successfully applied to capture endogenous phosphorylated peptides from human saliva. And consequently, a total of 30 phosphopeptides containing 2 multi- and 28 mono-phosphopeptides were identified efficiently. These results show that the novel materials have the great potential in peptidome analysis.
More Related Videos
Related Concept Videos
The Nucleosome Core Particle
The paradox
Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
Binary Fission
Binary Fission
Properties of Transition Metals
Oxidation Numbers
Salivary Glands and Saliva

