Related Experiment Video
Updated: Jan 21, 2026
05:56
A Traditional Chinese Medicine Characteristic Therapy for Bronchial Asthma: Moxibustion
Published on: May 12, 2023
5.1K
Asthma from immune pathogenesis to precision medicine.
Kareem Khalaf1, Giovanni Paoletti2, Francesca Puggioni2
1Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy.
Seminars in Immunology
|August 8, 2019
Summary
Asthma involves diverse immune mechanisms (endotypes) causing varied symptoms (phenotypes). Identifying these endotypes enables personalized treatments, especially for severe asthma, using targeted biological agents.
Area of Science:
- Immunology
- Pulmonology
- Pharmacology
Background:
- Asthma presents with diverse clinical features (phenotypes) driven by distinct immunological pathways (endotypes).
- Understanding these endotypes is key for accurate patient stratification and developing targeted therapies.
Purpose of the Study:
- To review the immunological mechanisms underlying asthma pathogenesis.
- To discuss the phenotypic variations in asthma.
- To explore novel biological agents and precision medicine approaches for specific asthma endotypes.
Main Methods:
- Literature review of immunological mechanisms in asthma.
- Analysis of asthma phenotypes and their association with endotypes.
- Discussion of targeted therapies, including novel biological agents.
Main Results:
- Asthma pathogenesis involves multiple complex immunological endotypes.
- Phenotypic diversity reflects underlying endotypic differences.
- Precision medicine, using targeted agents, is emerging as a crucial approach for severe asthma.
Conclusions:
- Identifying asthma endotypes is essential for personalized treatment strategies.
- Novel biological agents offer targeted therapies for specific immunological pathways.
- Precision medicine is vital for managing severe asthma effectively.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
1.3K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.3K
01:29Asthma-I: Introduction
3.4K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.4K
01:38What is the Immune System?
127.0K
Overview
127.0K
01:26Asthma-II: Pathophysiology and Classification
4.2K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.2K
01:24Asthma-III: Symptoms and Complications
3.3K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
3.3K
01:30Asthma-IV: Diagnostic and Management
3.1K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.1K