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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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Challenges and future of precision medicine strategies for breast cancer based on a database on drug reactions

Xiping Zhang1, Hongjian Yang1, Ruiping Zhang2

  • 1Department of Breast Surgery, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, Zhejiang Province, China.

Bioscience Reports
|August 8, 2019
PubMed

Insights

Traditional breast cancer (BC) precision medicine faces challenges due to limited patient numbers per subtype and tumor heterogeneity. A new approach focusing on individual drug reactions aims to improve treatment matching and efficacy for BC patients.

Area of Science:

  • Oncology
  • Pharmacogenomics
  • Translational Medicine

Background:

  • Breast cancer (BC) is a leading malignancy in women, with significant research invested in precision medicine.
  • Despite advances, traditional precision medicine strategies for BC have shown limited patient benefit.
  • Existing strategies often struggle with low drug match rates and overcoming tumor heterogeneity.

Purpose of the Study:

  • To analyze the limitations of current BC precision medicine strategies.
  • To propose novel precision medicine approaches for BC based on patient drug reactions.
  • To enhance therapeutic efficacy and drug utilization in breast cancer treatment.

Main Methods:

  • Analysis of traditional BC precision medicine strategies based on molecular subtypes.
  • Review of existing research on drug reactions in BC patients.
  • Development of a new strategy centered on individual patient drug responses.

Main Results:

  • Traditional BC precision medicine strategies exhibit deficiencies, including low patient-drug matching ratios.
  • Tumor heterogeneity in BC contributes to poor drug sensitivity and treatment outcomes.
  • A drug reaction-based approach shows potential to overcome limitations of molecular subtype-driven treatments.

Conclusions:

  • Current BC precision medicine, reliant on molecular subtypes, has inherent limitations.
  • A paradigm shift towards patient-specific drug reactions is proposed to improve BC treatment.
  • This new strategy aims to maximize existing drug utility and enhance therapeutic outcomes in BC.
Keywords:
breast cancerdatabasedrug reactionprecision medicinetargettranscriptome

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