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A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

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Published on: May 20, 2016

Reduction in apathy following epilepsy surgery.

Linda Mah^1,2,3, Joan Swearer⁴, Catherine A Phillips⁴

¹Rotman Research Institute, Baycrest, Toronto, Canada.

Neuropsychiatric Disease and Treatment

|August 8, 2019

Summary

Epilepsy surgery may reduce apathy in patients, though the direct link is unclear. The Frontal Systems Behavior Scale (FrSBe) shows promise for measuring behavioral changes after epilepsy surgery.

Keywords:

apathy disinhibition epilepsy surgery frontal lobe motivation temporal lobe epilepsy

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Area of Science:

Neuroscience
Behavioral Science
Neurosurgery

Background:

Epilepsy surgery can alter patient behavior, sometimes causing new neuropsychiatric symptoms or alleviating pre-existing ones.
Standard psychiatric diagnostic criteria may not accurately assess behavioral changes in epilepsy patients.
Frontal-subcortical dysfunction is a key concern in post-surgical epilepsy patients.

Purpose of the Study:

To assess the feasibility of using the Frontal Systems Behavior Scale (FrSBe) to measure behaviors linked to frontal-subcortical dysfunction.
To evaluate behavioral changes in patients who underwent surgical intervention for medically refractory epilepsy.

Main Methods:

Twenty-three epilepsy surgery patients and their family informants completed the FrSBe.
The FrSBe assesses executive dysfunction, disinhibition, and apathy before and after surgery.
Both patient and informant ratings were collected for pre- and post-surgical behaviors.

Main Results:

Informants reported a significant reduction in apathy post-surgery compared to executive dysfunction or disinhibition.
A trend suggested apathy reduction after right hemisphere resections.

Conclusions:

Epilepsy surgery patients exhibited reduced apathy, but the causal link to surgery requires further investigation.
The FrSBe appears useful for studying behavioral alterations following epilepsy surgery.
Dimensional scales like the FrSBe are recommended for future research on post-surgical behavioral changes.