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Related Experiment Videos

[Volatile organochlorine compounds in human tissue].

G Alles1, U Bauer, F Selenka

  • 1Institut für Hygiene der Ruhr-Universität Bochum.

Zentralblatt Fur Bakteriologie, Mikrobiologie Und Hygiene. Serie B, Umwelthygiene, Krankenhaushygiene, Arbeitshygiene, Praventive Medizin
|June 1, 1988
PubMed
Summary

Volatile organic chlorinated compounds, including chloroform, are present in all human tissues studied. Chloroform levels increase with age, particularly in fatty tissues, peaking between 50 and 70 years old.

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Area of Science:

  • Environmental Chemistry
  • Toxicology
  • Human Physiology

Context:

  • Investigated the presence and distribution of volatile organic chlorinated compounds (VOCCs) in human autopsy tissues.
  • Analyzed 150 tissue samples from 30 deceased individuals (ages 29-82).
  • Focused on subcutaneous adipose tissue, perinephric fat, liver, lung, and muscle tissue.

Purpose:

  • To quantify VOCCs in various human tissues.
  • To determine the prevalence of specific chlorinated compounds.
  • To explore correlations between VOCC levels, tissue type, and age.

Summary:

  • VOCCs, including chloroform, 1,1,1-trichloroethane, carbon tetrachloride, trichloroethylene, and tetrachloroethylene, were detected in all investigated human tissues.
  • Mean VOCC concentrations ranged from 2-25 µg/kg wet tissue, with chloroform being the most abundant.

Related Experiment Videos

  • Fatty tissues (subcutaneous and perinephric) showed higher VOCC levels than liver, lung, and muscle tissues, except for 1,1,1-trichloroethane.
  • Chloroform levels significantly increased with age, peaking between 50-70 years, independent of tissue fat content.

    • Impact:

    • Provides baseline data on human tissue contamination by VOCCs.
    • Highlights the accumulation of specific chlorinated compounds with aging.
    • Informs public health assessments regarding environmental exposure to chlorinated solvents.