Venous-to-arterial pCO₂ difference in high-risk surgical patients

Alteration of tissue perfusion is a main contributor to organ dysfunction in high-risk surgical patients. The difference between venous carbon dioxide and arterial carbon dioxide pressure (pCO₂ gap) has been described as a parameter reflecting tissue hypoperfusion in critically ill patients who are insufficiently resuscitated. The pCO₂ gap/CavO₂ ratio has also been described as an indicator of the respiratory quotient, thus the relationship between DO₂ and VO₂. Most of the knowledge about the pCO₂ gap and the pCO₂ gap/CavO₂ ratio has come from studies in the literature on animal models or intensive care unit (ICU) patients. To date, publications pertaining to the operative setting are sparse. In the present review, we will first discuss the physiological background of the pCO₂ gap and CO₂-O₂ derived parameters used in the operating room. Few studies have focused on the clinical relevance of the pCO₂ gap in high-risk non-cardiac surgical patients. Prospective observational studies with a small sample size and retrospective studies have shown that the pCO₂ gap may be a useful complementary tool to identify patients who remain insufficiently optimized hemodynamically. In a few studies, a high pCO₂ gap was associated with postoperative complications following non-cardiac high-risk surgery. Results of observational studies conducted in patients undergoing cardiac surgery are contradictory. We focused on the divergence between non-cardiac surgery, cardiac surgery, and septic critically ill patients. When analyzing the literature, we can find some explanations for the discrepancies in the published results between cardiac and non-cardiac surgery. Finally, we will discuss the clinical utility of the pCO₂ gap in high-risk surgical patients.