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The control of FSH secretion.
1MRC Reproductive Biology Unit, Edinburg, Scotland.
Acta Endocrinologica. Supplementum
|January 1, 1988
Summary
Follicle-stimulating hormone (FSH) release is primarily inhibited by estradiol and inhibin, acting on pituitary gonadotropes. These hormones, secreted by developing follicles and the corpus luteum, regulate FSH secretion and follicular development.
Area of Science:
- Reproductive Endocrinology
- Molecular Endocrinology
- Hormonal Regulation
Background:
- Follicle-stimulating hormone (FSH) secretion is a complex process involving multiple regulatory factors.
- The interplay between gonadotropes, gonadotropins, and gonadal steroids is crucial for reproductive cycles.
Purpose of the Study:
- To elucidate the primary mechanisms inhibiting FSH synthesis and release.
- To investigate the roles of estradiol and inhibin in regulating FSH secretion and follicular development.
Main Methods:
- Analysis of hormonal feedback mechanisms at the pituitary gonadotrope level.
- In vivo assessment of estradiol's effect on FSH levels during estrus/menstrual cycles.
- Examination of the synergistic action of estradiol and inhibin.
Main Results:
- FSH secretion is mainly controlled by factors inhibiting synthesis and release at the pituitary gonadotrope level.
- Estradiol directly inhibits FSH release by suppressing mRNA transcription in gonadotropes.
- Estradiol acts synergistically with inhibin, both secreted by developing follicles, to regulate FSH levels.
Conclusions:
- Estradiol and inhibin are key regulators of FSH secretion, acting directly on pituitary gonadotropes.
- The combined action of estradiol, inhibin, and progesterone suppresses FSH, thereby controlling follicular development during the luteal phase.