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Updated: Jan 21, 2026

X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease
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X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease

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Probing the structural interactions between methotrexate and dexamethasone with muscle cystatin: a biophysical study

Mohammad Aatif1, Aaliya Shah2, Medha Priyadarshini3

  • 1Department of Public Health, College of Applied Medical Sciences, King Faisal University, Al Ahsa, Kingdom Saudi Arabia.

Journal of Biomolecular Structure & Dynamics
|August 8, 2019
PubMed
Summary

This study investigated the interaction between muscle cystatin and anti-rheumatic drugs, methotrexate and dexamethasone. Spectroscopic analysis revealed static quenching interactions, providing insights for developing new rheumatoid arthritis drugs.

Keywords:
Methotrexatecystatindexamethasonefluorescence transform infra-red spectroscopymuscle cystatinultra-violet

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