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Consumption of the benzodiazepine clonazepam (Rivotril®) in Rio de Janeiro State, Brazil, 2009-2013: an ecological
Rafaela Teixeira Zorzanelli1, Fabíola Giordani2, Lusiele Guaraldo3
1Instituto de Medicina Social, Universidade Estadual do Rio de Janeiro. R. São Francisco Xavier 524/Pavilhão João Lyra Filho/7º/bls. D e E, Maracanã. 20550-900 Rio de Janeiro RJ Brasil. rtzorzanelli@hotmail.com.
Ciencia & Saude Coletiva
|August 8, 2019
Summary
Clonazepam consumption in Rio de Janeiro increased significantly from 2009-2013, with up to 2% of adults possibly using it as a sedative. This widespread use warrants attention due to abuse potential.
Area of Science:
- Pharmacovigilance
- Public Health
- Epidemiology
Background:
- Clonazepam is a benzodiazepine with anticonvulsant and sedative-hypnotic properties.
- Understanding its consumption patterns is crucial for public health monitoring.
Purpose of the Study:
- To estimate clonazepam consumption prevalence in Rio de Janeiro State from 2009 to 2013.
- To analyze consumption trends based on population demographics and socioeconomic factors.
Main Methods:
- Descriptive, ecological study using Anvisa's National Controlled Product Management System data.
- Consumption measured in Daily Defined Doses (DDD) per 1000 population (using 1mg and 8mg DDD).
- Municipalities analyzed based on Human Development Index (HDI) and GINI index.
Main Results:
- Statewide clonazepam consumption rose from 0.35 to 1.97 DDD/1000 population (2009-2013).
- Using a 1mg DDD, 2013 consumption reached 21 DDD/1000 adults (>18 years).
- Highest consumption in 2013 observed in Rio de Janeiro and Niterói, correlating with high HDI.
Conclusions:
- An estimated 2% of the adult population in Rio de Janeiro may use clonazepam, potentially as a sedative-hypnotic.
- Broad usage and off-label indications highlight concerns regarding clonazepam's abuse potential and adverse effects.
- Further pharmacovigilance is recommended to monitor clonazepam use and mitigate risks.
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