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HLA-DPA1 gene polymorphism in primary glaucoma.

J-H Li1, J-F Shao, Z-G Sui

  • 1Department of Laboratory Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China. yiwugongzuo@126.com.

European Review for Medical and Pharmacological Sciences
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Human Leukocyte Antigen (HLA)-DPA1 gene variations may influence primary glaucoma severity. Specific single nucleotide polymorphisms (SNPs) showed genetic correlations, suggesting a link between HLA-DPA1 and glaucoma.

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Area of Science:

  • Genetics
  • Ophthalmology
  • Immunogenetics

Background:

  • Primary glaucoma is a leading cause of irreversible blindness worldwide.
  • The role of genetic factors, particularly human leukocyte antigen (HLA) genes, in primary glaucoma pathogenesis is increasingly recognized.
  • Understanding the genetic associations can aid in risk stratification and early detection.

Purpose of the Study:

  • To investigate the association between human leukocyte antigen (HLA)-DPA1 gene polymorphism and primary glaucoma.
  • To identify specific single nucleotide polymorphisms (SNPs) within the HLA-DPA1 gene that may be linked to glaucoma development or severity.

Main Methods:

  • Genotyping of six single nucleotide polymorphisms (SNPs) in the HLA-DPA1 gene was performed using Polymerase Chain Reaction (PCR).
  • The study included 51 patients diagnosed with primary glaucoma and 51 healthy controls.
  • Statistical analyses, including t-tests and Chi-square tests, were employed to detect associations.

Main Results:

  • A significant genetic correlation was observed for the rs1676486 genotype.
  • Rs3753841 and rs12138977 genotypes exhibited a higher minor-allele frequency in the control group.
  • The CT + CC genotype of rs12138977 showed a significant genetic correlation in both cases and controls, while its influence on primary angle-closure glaucoma (PACG) occurrence was minimal. Intraocular hypertension and short axial length were identified as primary risk factors for PACG.

Conclusions:

  • Human Leukocyte Antigen (HLA)-DPA1 gene polymorphism may be associated with the severity of primary angle-closure glaucoma (PACG).
  • Further research is warranted to elucidate the precise mechanisms linking HLA-DPA1 to glaucoma.