Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas

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Updated: Jan 21, 2026

Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets
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Genome-wide Analysis using ChIP to Identify Isoform-specific Gene Targets

Published on: July 7, 2010

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Christian W Johnson1, Yi-Jang Lin2, Derion Reid1

  • 1Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.

Cell Reports
|August 8, 2019
PubMed

Keywords:
KRas G12DKRas G13D mouse modelKRas G13D structuresRas GTPasesRas conformational statesactivation cyclecolorectal cancernucleotide exchange mutantoncogene

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