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Correlation between Vestibular Evoked Myogenic Potentials and Disease Progression in Ménière's Disease
Eka Kharkheli1, S Japaridze2, Zuriko Kevanishvili1
1National Centre of Audiology, Tbilisi, Georgia.
Objective:
To assess the relationship between ocular (oVEMPs) and cervical (cVEMPs) vestibular evoked myogenic potentials and audiometrically determined clinical stage in Ménière's disease (MD).
Methods:
Thirty-four unilateral MD patients and 30 healthy volunteers were included in the study. Pure-tone hearing levels, oVEMPs, cVEMPs, and videonystagmography results were analyzed and compared between the groups.
Results:
Both oVEMPs and cVEMPs were highly reproducible in the control group. At the early stages of MD, cVEMPs were particularly disturbed, while at the advanced stages both oVEMPs and cVEMPs were altered pathologically. In the study group, oVEMP and cVEMP amplitudes and interaural amplitude difference (IAD) statistically differed from those in the control sample. oVEMPs were absent in 7.7% of stage III and in 44.5% of stage IV MD patients, while cVEMPs were absent in 15.4% of stage III and in 54.5% of stage IV MD patients, respectively. In stage III and IV MD patients in whom oVEMPs and cVEMPs were obtained, IADs were increased. Caloric asymmetry was found in 64.7% of MD patients. Caloric weakness was more prominent in cases with advanced MD.
Conclusion:
VEMPs can be used for objective validation of the stage of MD.
Insights
Vestibular evoked myogenic potentials (VEMPs) can objectively validate Ménière
Area of Science:
- Otolaryngology
- Neuroscience
- Audiology
Background:
- Ménière's disease (MD) is a disorder of the inner ear.
- Accurate staging of MD is crucial for treatment and prognosis.
- Objective measures are needed to complement subjective symptoms and audiometry.
Purpose of the Study:
- To evaluate the correlation between ocular (oVEMPs) and cervical (cVEMPs) vestibular evoked myogenic potentials and the clinical stage of Ménière's disease.
- To determine the utility of VEMPs in objectively assessing MD progression.
Main Methods:
- Study included 34 unilateral MD patients and 30 healthy controls.
- Evaluated pure-tone hearing levels, oVEMPs, cVEMPs, and videonystagmography.
- Compared VEMP parameters (amplitude, interaural amplitude difference) between patient stages and controls.
Main Results:
- Both oVEMPs and cVEMPs showed high reproducibility in controls.
- cVEMPs were impaired early in MD; both oVEMPs and cVEMPs were pathologically altered in advanced stages.
- VEMP amplitudes and interaural amplitude differences were significantly different in MD patients compared to controls, with increasing abnormalities in later stages (III and IV).
Conclusions:
- Vestibular evoked myogenic potentials (VEMPs) serve as a reliable objective tool for validating the clinical stage of Ménière's disease.
- VEMP testing can aid in the objective assessment and management of MD progression.