[Induction of sarcomas by a nontumorigenic type of foreign body and glutaraldehyde]

Nontumorigenic form of cellophane has been implanted subcutaneously into rats, and simultaneously an injection of 0.5 ml 2.5% buffered glutaraldehyde has been given at the site of implantation. Glutaraldehyde injections at the same site were repeated at 4 consecutive days. This treatment induced sarcomas in 21 out of 33 rats (63.6%). Mean latency period of tumor development was 15.7 months. Tumours were diagnosed as polymorphocellular, undifferentiated sarcomas, fibrosarcomas.