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Updated: Jan 21, 2026
09:41
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
9.1K
[Ectopic pulmonary calcification after parathyroidectomy in multiple myeloma]
Koji Ando1, Yoshitaka Imaizumi1, Kazuko Yamamoto2
1Department of Hematology, Nagasaki University Hospital.
Summary
This case study highlights rapid ectopic soft tissue calcification (ESTC) in a multiple myeloma patient with hypoparathyroidism. Treatment with ferric citrate hydrate and calcium improved pulmonary symptoms, suggesting a potential therapeutic approach.
Area of Science:
- Nephrology
- Oncology
- Endocrinology
Background:
- Ectopic soft tissue calcification (ESTC) is a rare condition causing organ damage, often linked to chronic renal failure, hyperparathyroidism, and malignancies like multiple myeloma.
- ESTC is frequently resistant to conventional treatments, posing significant clinical challenges.
Observation:
- A 71-year-old male with multiple myeloma and secondary hypoparathyroidism developed rapid ectopic pulmonary calcification.
- The calcification onset occurred approximately two weeks post-infection, independent of multiple myeloma progression.
Findings:
- Treatment with ferric citrate hydrate and precipitated calcium led to prompt improvement in pulmonary signs associated with ectopic calcification.
- The patient's multiple myeloma showed no further progression after the onset of ESTC.
Implications:
- Patients with multiple myeloma and hypoparathyroidism require vigilant monitoring for early detection of ectopic calcification.
- Effective management of hypophosphatemia is crucial in preventing or treating ectopic calcification in susceptible individuals.
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