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Neonatal ibuprofen exposure and bronchopulmonary dysplasia in extremely premature infants

Xueyu Chen1, Xiaomei Qiu1, Panpan Sun1

  • 1Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, China.

Journal of Perinatology : Official Journal of the California Perinatal Association
|August 9, 2019
PubMed

Insights

Early ibuprofen exposure in extremely premature infants was linked to a higher risk of bronchopulmonary dysplasia (BPD). This suggests ibuprofen may contribute to BPD development in these vulnerable infants.

Area of Science:

  • Neonatalogy
  • Pediatric Pulmonology
  • Pharmacology

Background:

  • Bronchopulmonary dysplasia (BPD) is a significant complication in extremely premature infants.
  • The role of early pharmacological interventions, such as ibuprofen, in BPD development requires further investigation.

Purpose of the Study:

  • To evaluate the association between early ibuprofen exposure and the risk of developing bronchopulmonary dysplasia (BPD) in extremely premature infants.

Main Methods:

  • Retrospective study design.
  • Inclusion of 203 extremely premature infants admitted to a tertiary unit between 2016 and 2018.
  • Statistical analysis comparing BPD rates between infants with and without early ibuprofen exposure, adjusting for covariates.

Main Results:

  • The rate of BPD was significantly higher in infants with early ibuprofen exposure (42.5%) compared to those without exposure (21.6%, P=0.001).
  • Ibuprofen exposure was independently associated with an increased risk of BPD (OR 2.296, 95% CI: 1.166-4.522, p=0.016).
  • A trend towards higher BPD risk was observed in infants with successful patent ductus arteriosus (PDA) closure after ibuprofen treatment compared to non-treated infants (32.3% vs 20.2%, p=0.162).

Conclusions:

  • Ibuprofen exposure may be a contributing factor to the development of BPD in extremely preterm infants.
  • Further research is warranted to elucidate the specific mechanisms and clinical implications.
Abstract

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