Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

4.0K
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
4.0K
Accessory Ducts of the Male Reproductive System01:25

Accessory Ducts of the Male Reproductive System

3.1K
The male reproductive system is a complex network of organs and tissues that work together to produce and transport sperm. The epididymis, vasa deferens, ejaculatory ducts, and urethra are the accessory ducts involved in sperm maturation and transportation. These ducts play a critical role in the production and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle....
3.1K
Accessory Glands of the Male Reproductive System01:16

Accessory Glands of the Male Reproductive System

3.3K
The accessory ducts involved in sperm maturation and transportation include the epididymides, vasa deferentia, ejaculatory ducts, and urethra. These ducts play a critical role in the maturation, storage, and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
3.3K
Reproductive Cloning01:27

Reproductive Cloning

32.6K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.6K
Obesity01:24

Obesity

1.2K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.2K
Role of Affect in Interpersonal Attraction01:24

Role of Affect in Interpersonal Attraction

217
Affect plays a crucial role in shaping interpersonal evaluations and perceptions. Emotions influence how individuals judge and respond to others, often determining whether interactions are viewed positively or negatively. This effect can manifest directly through interactions with the person in question or indirectly via associations with unrelated emotional experiences.Direct Effects of Affect on AttractionAffect directly influences interpersonal attraction when a person’s behavior...
217

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune checkpoint blockade for Merkel cell carcinoma: actual findings and unanswered questions.

Journal of cancer research and clinical oncology·2019
Same author

Human exposure to bisphenol AF and diethylhexylphthalate increases susceptibility to develop differentiated thyroid cancer in patients with thyroid nodules.

Chemosphere·2019
Same author

Role of Nutrition and Adherence to the Mediterranean Diet in the Multidisciplinary Approach of Hidradenitis Suppurativa: Evaluation of Nutritional Status and Its Association with Severity of Disease.

Nutrients·2019
Same author

Gender-related issues in the pharmacology of new anti-obesity drugs.

Obesity reviews : an official journal of the International Association for the Study of Obesity·2018
Same author

Trimethylamine-N-oxide (TMAO) as Novel Potential Biomarker of Early Predictors of Metabolic Syndrome.

Nutrients·2018
Same author

Retraction: HMGA Proteins Up-regulate <i>CCNB2</i> Gene in Mouse and Human Pituitary Adenomas.

Cancer research·2018

Related Experiment Video

Updated: Jan 21, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

414

How much does obesity affect the male reproductive function?

Giuseppe Bellastella1, Davide Menafra2, Giulia Puliani3

  • 11Unit of Endocrinology and Metabolic Diseases, Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Naples, Italy.

International Journal of Obesity Supplements
|August 9, 2019
PubMed
Summary

Obesity negatively impacts male fertility through various factors affecting sperm quality and reproductive hormones. Weight loss can help restore gonadal hormone levels and improve reproductive health.

More Related Videos

Agrobacterium-Mediated Genetic Transformation, Transgenic Production, and Its Application for the Study of Male Reproductive Development in Rice
07:43

Agrobacterium-Mediated Genetic Transformation, Transgenic Production, and Its Application for the Study of Male Reproductive Development in Rice

Published on: October 6, 2020

13.2K
Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
04:37

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Published on: May 12, 2019

16.3K

Related Experiment Videos

Last Updated: Jan 21, 2026

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

414
Agrobacterium-Mediated Genetic Transformation, Transgenic Production, and Its Application for the Study of Male Reproductive Development in Rice
07:43

Agrobacterium-Mediated Genetic Transformation, Transgenic Production, and Its Application for the Study of Male Reproductive Development in Rice

Published on: October 6, 2020

13.2K
Reproductive Techniques for Ovarian Monitoring and Control in Amphibians
04:37

Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

Published on: May 12, 2019

16.3K

Area of Science:

  • Reproductive Endocrinology
  • Obesity Medicine
  • Spermatology

Background:

  • Obesity is a global epidemic linked to numerous health issues.
  • The relationship between male obesity and fertility is complex and requires further clarification.
  • Existing evidence on obesity's impact on male fertility is often contradictory.

Purpose of the Study:

  • To comprehensively review the multifaceted relationship between obesity and male fertility.
  • To analyze evidence from in vitro, in vivo, and clinical studies.
  • To propose a novel classification of factors influencing the hypothalamic-pituitary-gonadal axis in obese males.

Main Methods:

  • Systematic literature review encompassing in vitro, in vivo, and clinical trial data.
  • Analysis of studies investigating obesity's direct and indirect effects on male reproductive health.
  • Examination of research on obesity-related epigenetic modifications in sperm.
  • Review of studies on the impact of weight loss interventions on male fertility.

Main Results:

  • Obesity is associated with secondary hypogonadism and disruptions in the hypothalamic-pituitary-gonadal axis.
  • Direct effects of obesity on sperm parameters include impaired Sertoli cell function, elevated scrotal temperature, oxidative stress, and toxic substance accumulation.
  • Obesity-related epigenetic changes in sperm may affect offspring health.
  • Obesity is linked to reduced success rates in assisted reproductive technologies and increased pregnancy loss.
  • Weight loss interventions (diet, bariatric surgery) show potential for restoring gonadal hormone levels.

Conclusions:

  • Obesity presents a significant threat to male fertility through hormonal, cellular, and epigenetic mechanisms.
  • A proposed classification highlights central, peripheral, and testicular factors contributing to reproductive dysfunction in obese males.
  • Weight reduction strategies are crucial for managing obesity-related male reproductive impairments and improving fertility outcomes.