Related Experiment Video

Updated: Jan 21, 2026

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice
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Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice

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Dopaminergic D1 receptor signalling is necessary, but not sufficient for cued fear memory destabilisation

Charlotte R Flavell1, Jonathan L C Lee2

  • 1School of Psychology, University of Birmingham, Hills Building, Edgbaston, Birmingham, B15 2TT, UK.

Psychopharmacology
|August 9, 2019
PubMed
Abstract

Insights

Targeting memory reconsolidation shows promise for fear disorders. Nefiracetam combined with mifepristone, dependent on dopamine D1 receptors, aids memory disruption without increasing fear.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Psychiatry

Background:

  • Memory reconsolidation targeting is a key strategy for fear-related disorders.
  • Effective fear memory destabilization via reactivation is crucial for therapeutic success.

Purpose of the Study:

  • Investigate the role of dopamine D1 receptors in cued fear memory destabilization.
  • Assess the potential of pharmacological interventions for memory reconsolidation disruption.

Main Methods:

  • Systemic administration of drugs targeting dopamine D1 receptors.
  • Utilized nefiracetam and mifepristone to assess memory destabilization and reconsolidation disruption.
  • Evaluated effects on fear memory expression and extinction learning.

Main Results:

  • Direct dopamine D1 receptor agonism alone did not destabilize fear memory for disruption.
  • Nefiracetam facilitated mifepristone-induced amnesia, contingent on dopamine D1 receptor activation.
  • Combined nefiracetam and mifepristone did not enhance fear reduction during extinction; mifepristone alone showed some fear reduction.

Conclusions:

  • Combination pharmacological treatments can target memory destabilization and impair reconsolidation.
  • This approach offers therapeutic potential for fear memory disorders without increasing maladaptive fear.
Keywords:
DestabilisationDopamineExtinctionFearGlucocorticoidMifepristoneNefiracetamReconsolidation

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