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Optimising antimicrobial therapy through the use of Bayesian dosing programs
M L Avent1,2, B A Rogers3,4
1Infection and Immunity Theme, UQ Centre for Clinical Research (UQCCR), The University of Queensland, Level 5, Building 71/918 Royal Brisbane Hospital, Herston, QLD, 4006, Australia. m.avent@uq.edu.au.
Abstract:
The optimisation of antibiotic dosing therapy with therapeutic drug monitoring is widely recommended. The aim of therapeutic drug monitoring is to help the clinician to achieve target pharmacokinetic/pharmacodynamic parameters, maximising efficacy and minimising toxicity. Computerised programs, utilising the Bayesian estimation procedures, are able to achieve target concentrations in a greater percentage of patients earlier in the course of therapy compared to linear regression analysis and population methods. This article summarises various methods for dose optimisation of antibiotics with a focus on Bayesian programs.
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