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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Communication01:03

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Communication between two animals occurs when one animal transmits an information signal that causes a change in the animal that receives the information. Organisms communicate with one another in a host of different ways. Signals can be auditory, chemical, visual, tactile, or a combination of these. Communication is a critical behavioral adaptation that promotes survival, growth, and reproduction.
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Communication01:28

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Sharing information, concepts, and emotions to foster mutual understanding is communication. The sender, recipient, and transaction must be considered in this manner. The sender is the person who shares the message, the recipient is the person who receives and understands the message, and the transaction is the method used to deliver the message and the variables that affect the communication's context and surroundings. The nurse-client connection is built on therapeutic communication.
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Common Ion Effect03:24

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Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Châtelier’s principle. Consider the dissolution of silver iodide:
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Therapeutic Communication01:30

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Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
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Related Experiment Video

Updated: Jan 21, 2026

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
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Epigenetics and Common Non Communicable Disease.

Mohammad Amin Tabatabaiefar1,2,3, Roshanak S Sajjadi4, Sina Narrei5

  • 1Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. tabatabaiefar@med.mui.ac.ir.

Advances in Experimental Medicine and Biology
|August 9, 2019
PubMed
Summary

Non-communicable diseases (NCDs) like cancer and diabetes are rising. Epigenetic mechanisms, including DNA methylation and non-coding RNAs, offer new ways to predict and prevent these major global health threats.

Keywords:
CancerChromatin modificationsDNA methylationDiabetesEpigeneticsSchizophreniancRNA

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Area of Science:

  • Genomic Medicine
  • Molecular Biology
  • Public Health

Background:

  • Non-communicable diseases (NCDs) are the leading global cause of mortality.
  • NCDs arise from complex interactions between genetic, lifestyle, and environmental factors.
  • Increasing NCD prevalence necessitates novel prediction and prevention strategies.

Purpose of the Study:

  • To explore the role of epigenetics in the etiology of major NCDs.
  • To discuss epigenetic mechanisms relevant to cancer, diabetes, and schizophrenia.
  • To highlight the potential of epigenetic insights for early disease detection and prevention.

Main Methods:

  • Review of epigenetic alterations including DNA methylation, chromatin modification, and non-coding RNAs (ncRNAs).
  • Focus on the application of these mechanisms in understanding cancer, diabetes, and schizophrenia.
  • Categorization of epigenetic mechanisms into DNA methylation/chromatin modifications and ncRNAs.

Main Results:

  • Epigenetic alterations are key contributors to NCD development.
  • Specific epigenetic mechanisms are implicated in the pathogenesis of cancer, diabetes, and schizophrenia.
  • Understanding these mechanisms can lead to predictive and preventive strategies.

Conclusions:

  • Epigenetic insights provide a promising avenue for the early prediction, detection, and prevention of NCDs.
  • Targeting epigenetic modifications may offer novel therapeutic strategies for NCDs.
  • Further research into epigenetic mechanisms is crucial for combating the global burden of NCDs.