Oxidative stress involvement in psoriasis: a systematic review

Area of Science:

• Dermatology
• Biochemistry
• Immunology

Background:

• Psoriasis is a chronic inflammatory skin condition with complex origins.
• An imbalance in the body's antioxidant system and increased reactive oxygen species (ROS) contribute to its pathogenesis.
• Oxidative stress is implicated in the development of various diseases, including psoriasis.

Purpose of the Study:

• To provide an updated review on the role of oxidative stress in psoriasis.
• To identify potential biomarkers for the disease.
• To explore innovative therapeutic strategies.

Main Methods:

• A systematic review of 28 relevant studies was conducted.
• Studies investigating the link between oxidative stress markers and psoriasis were analyzed.
• Biomarker eligibility and clinical relevance were assessed.

Main Results:

• Several molecules were associated with psoriasis, but only a few qualified as potential biomarkers: malondialdehyde (MDA), total oxidative stress, and oxidative stress index.
• Malondialdehyde (MDA) emerged as the most promising biomarker, showing a strong correlation with the Psoriasis Area Severity Index (PASI).

Conclusions:

• Oxidative stress is a significant factor in psoriasis pathogenesis.
• MDA is a strong candidate for clinical screening of psoriasis patients.
• Therapies including medication, lifestyle changes, and antioxidant-rich diets may help mitigate oxidative stress damage in psoriasis.