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Distribution of Capsular Types of Campylobacter jejuni Isolates from Symptomatic and Asymptomatic Children in Peru

Jesús D Rojas1,2, Nathanael D Reynolds1, Brian L Pike3

  • 1Bacteriology Department, Naval Medical Research Unit-6 (NAMRU-6), Lima, Peru.

The American Journal of Tropical Medicine and Hygiene
|August 9, 2019
PubMed

Insights

Capsular polysaccharide (CPS) type distribution in Peru differs from other regions, with HS4 complex being most prevalent. Understanding these variations is crucial for developing effective Campylobacter jejuni vaccines.

Area of Science:

  • Microbiology
  • Vaccinology
  • Epidemiology

Background:

  • Campylobacter jejuni is a primary cause of bacterial diarrhea globally.
  • A capsular polysaccharide (CPS) conjugate vaccine is in development, necessitating knowledge of circulating CPS types.
  • Global distribution data for Campylobacter jejuni CPS types is limited.

Purpose of the Study:

  • To investigate the distribution of Campylobacter jejuni CPS types in Peru.
  • To compare Peruvian CPS type distribution with other endemic regions.
  • To inform the valency determination for a Campylobacter jejuni CPS conjugate vaccine.

Main Methods:

  • Utilized a multiplex polymerase chain reaction (PCR) assay.
  • Detected CPS encoding genes for all 35 known CPS types.
  • Analyzed isolates from two prospective community-based studies in Peru involving children under 59 months.

Main Results:

  • The HS4 complex was the most prevalent CPS type, followed by HS3 complex and HS15.
  • No statistically significant differences in symptomatology were associated with CPS type.
  • Repeated infections with different CPS types suggest potential for homologous protective immunity.

Conclusions:

  • Campylobacter jejuni CPS type distribution in Peru shows some differences compared to other low-middle income countries.
  • Further research in endemic areas is needed to refine understanding of CPS type distribution.
  • This data is vital for guiding the development of Campylobacter jejuni vaccines.

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