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Updated: Jan 21, 2026

Author Spotlight: Unveiling the Structural and Dynamic Aspects of Glycan Molecular Recognition
Published on: May 17, 2024
Synthesis and Glycan-Protein Interaction Studies of Se-Sialosides by 77Se NMR
Tatsuya Suzuki1, Chieka Hayashi1, Naoko Komura2
1Department of Applied Bioorganic Chemistry , Gifu University , 1-1, Yanagido , Gifu-shi, Gifu 501-1193 , Japan.
Abstract:
To expand the potential of Se-carbohydrates for multifunctional mimicry of sugars, herein we addressed the synthesis of the highly challenging and biologically significant Se-glycosides of sialic acid (Se-sialosides). An α-sialyl selenolate anion generated in situ smoothly reacted with electrophiles to give α-Se-sialosides as single stereoisomers. A Se-sialoside was sequentially incorporated with selenium, producing a triseleno-sialoside. This molecule was used as a 77Se NMR-active handle for studying glycan-protein interaction, revealing different binding profiles of sialic acid binding proteins.
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