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Pharmacokinetics of thio-TEPA at two different doses
B Hagen1, R A Walstad, O G Nilsen
1Department of Pharmacology and Toxicology, University of Trondheim, Norway.
Cancer Chemotherapy and Pharmacology
|January 1, 1988
Abstract:
Thio-TEPA pharmacokinetics were studied at doses of 20 mg and 30 mg in six patients treated for ovarian cancer. Considerable interindividual variation was encountered in its pharmacokinetics, which were dose-independent within the dose range studied and similar to those reported at far higher doses. Interindividual dosing of thio-TEPA based on an initial AUC estimation is suggested.